Paromomycin Sulfate
Also known as: Humatin, Gabbroral, Aminosidine, Leshcutan
CAS Number: 1263-89-4
Aminoglycoside Antibacterial / Antiprotozoal
Pharmacopeia Standards
Mechanism of Action
Paromomycin binds the 30S ribosomal subunit and causes misreading of mRNA, disrupting protein synthesis in susceptible bacteria and in protozoal parasites that possess prokaryote-like organellar ribosomes. Negligible oral absorption confines activity to the intestinal lumen when given by mouth. Parenteral and topical formulations exploit its antileishmanial activity.
Technical Specifications
| Generic / INN Name | Paromomycin Sulfate |
| CAS Registry Number | 1263-89-4 |
| Molecular Formula | C23H45N5O14 . H2SO4 |
| Molecular Weight | 713.71 g/mol (615.63 free base) g/mol |
| Typical Purity | NLT 675 micrograms of paromomycin per mg on the anhydrous basis (USP); related aminoglycosides within monograph limits |
| Storage Conditions | Store below 25 degrees C in airtight moisture-barrier containers with desiccant; hygroscopic |
| Shelf Life | 36 months from date of manufacture |
| Category | Aminoglycosides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral capsules for intestinal amoebiasis and hepatic coma adjunct use, intramuscular injection for visceral leishmaniasis, and topical creams for cutaneous leishmaniasis. A WHO essential medicine for leishmaniasis programmes.
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