Plazomicin Sulfate
Also known as: Zemdri
CAS Number: 1380078-95-4
Aminoglycoside Antibacterial (Reserve)
Mechanism of Action
Plazomicin binds the 30S ribosomal subunit, inducing mRNA misreading and blocking translocation to produce rapid concentration-dependent bactericidal killing. Its hydroxy-aminobutyric acid substituent at N1 and hydroxyethyl group at 6-prime sterically block almost all clinically important aminoglycoside-modifying enzymes. It therefore retains activity against many carbapenem-resistant and ESBL-producing Enterobacterales, though it is defeated by 16S rRNA methyltransferases.
Technical Specifications
| Generic / INN Name | Plazomicin Sulfate |
| CAS Registry Number | 1380078-95-4 |
| Molecular Formula | C25H48N6O10 . 2.5H2SO4 |
| Molecular Weight | 837.89 g/mol (592.68 free base) g/mol |
| Typical Purity | NLT 97.0% by HPLC on the free base anhydrous basis; sulfate content 2.3-2.7 molar equivalents; endotoxin NMT 0.20 EU/mg |
| Storage Conditions | Store at 2-8 degrees C in airtight light-resistant containers under aseptic control; hygroscopic |
| Shelf Life | 24 months from date of manufacture under refrigerated storage |
| Category | Aminoglycosides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile aqueous solution for intravenous infusion for complicated urinary tract infection. Sterile-grade API for aseptic fill only; there is no oral or topical presentation.
Manufacturers (0+)
View all →Do you manufacture Plazomicin Sulfate? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Plazomicin Sulfate? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent