Polymyxin B Sulfate
Also known as: Aerosporin, Polymyxin B for Injection, Polytrim, Neosporin and Polysporin components
CAS Number: 1405-20-5
Cyclic polypeptide (polymyxin) antibacterial
Pharmacopeia Standards
Mechanism of Action
Polymyxin B is a cationic cyclic decapeptide whose positively charged diaminobutyric acid residues bind the anionic lipid A of Gram-negative lipopolysaccharide, displacing the stabilising calcium and magnesium bridges. This disorganises the outer membrane, allows the fatty acyl tail to insert into the cytoplasmic membrane, and causes leakage of intracellular contents and rapid cell death. The same lipid A affinity gives it endotoxin-neutralising activity.
Technical Specifications
| Generic / INN Name | Polymyxin B Sulfate |
| CAS Registry Number | 1405-20-5 |
| Molecular Formula | C55H96N16O13 . 2H2SO4 (mixture, principally components B1 and B2) |
| Molecular Weight | 1385.61 g/mol as the sulfate salt; multi-component natural mixture g/mol |
| Typical Purity | NLT 6000 polymyxin B units per mg on anhydrous basis (USP); endotoxin controlled for sterile grade |
| Storage Conditions | Store at 2-8 C in tight, light-resistant containers; hygroscopic, keep sealed and protect from moisture |
| Shelf Life | 36 months from date of manufacture under refrigerated storage |
| Category | Lipopeptides & Polypeptides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Powder for intravenous, intramuscular and intrathecal injection for carbapenem-resistant Gram-negative infection, ophthalmic and otic drops, topical antibiotic ointments in combination with neomycin and bacitracin, and bladder irrigation solutions.
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