Posaconazole
Also known as: Noxafil, Posanol, Posacon, Posatral
CAS Number: 171228-49-2
Second-generation triazole antifungal — systemic, extended spectrum
Pharmacopeia Standards
Mechanism of Action
Posaconazole inhibits lanosterol 14-alpha-demethylase with very high affinity, and its extended lipophilic tail makes additional contact with the enzyme substrate channel. This yields the broadest azole spectrum in clinical use, including reliable activity against Mucorales, which most other triazoles lack. Ergosterol depletion combined with accumulation of methylated sterol intermediates compromises membrane integrity and arrests fungal growth.
Technical Specifications
| Generic / INN Name | Posaconazole |
| CAS Registry Number | 171228-49-2 |
| Molecular Formula | C37H42F2N8O4 |
| Molecular Weight | 700.78 g/mol |
| Typical Purity | 98.0–102.0% (on anhydrous basis) |
| Storage Conditions | Store below 25°C in tightly closed, light-resistant containers with double LDPE liner; protect from moisture |
| Shelf Life | 36 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients, oropharyngeal candidiasis refractory to fluconazole, salvage therapy of mucormycosis, fusariosis and chromoblastomycosis
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