Praziquantel
Also known as: Biltricide, Cesol, Distocide, Cysticide, Praziquantel Arpraziquantel
CAS Number: 55268-74-1
Anthelmintic (Pyrazinoisoquinoline, Antitrematodal/Anticestodal)
Pharmacopeia Standards
Mechanism of Action
Praziquantel rapidly increases calcium permeability across the schistosome and cestode tegument, most likely by acting on a transient receptor potential channel of the TRPM subfamily. The calcium influx produces violent muscular contraction, tegumental vacuolisation and disruption, exposing parasite antigens to host immune attack. Adult flukes and tapeworms are affected, while immature schistosomula are relatively refractory.
Technical Specifications
| Generic / INN Name | Praziquantel |
| CAS Registry Number | 55268-74-1 |
| Molecular Formula | C19H24N2O2 |
| Molecular Weight | 312.41 g/mol g/mol |
| Typical Purity | Not less than 98.5% (assay), on the dried basis |
| Storage Conditions | Store in well-closed containers below 30°C; protect from light and moisture |
| Shelf Life | 60 months in original sealed packaging |
| Category | Anthelmintics |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Film-coated and scored tablets for schistosomiasis mass drug administration, foodborne trematode infection and taeniasis or neurocysticercosis; paediatric orodispersible presentations; substantial veterinary and aquaculture use.
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