Pretomanid
Also known as: Dovprela, Pretomanid, Pa
CAS Number: 187235-37-6
Antitubercular (Nitroimidazooxazine)
Pharmacopeia Standards
Mechanism of Action
Pretomanid is a bicyclic nitroimidazooxazine prodrug reduced by the F420-dependent nitroreductase Ddn of Mycobacterium tuberculosis. Under aerobic conditions the activated drug inhibits mycolic acid biosynthesis and cell wall formation, while under anaerobic conditions it releases reactive nitrogen species including nitric oxide that poison cytochrome oxidase. This dual aerobic and anaerobic killing is what allows it to shorten regimens against persistent bacilli.
Technical Specifications
| Generic / INN Name | Pretomanid |
| CAS Registry Number | 187235-37-6 |
| Molecular Formula | C14H12F3N3O5 |
| Molecular Weight | 359.26 g/mol g/mol |
| Typical Purity | Not less than 98.0% (in-house HPLC, on anhydrous basis) |
| Storage Conditions | Store below 25 degrees C in tightly closed, light-resistant containers in a dry place; protect from light and moisture |
| Shelf Life | 36 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 200 mg pretomanid tablets used exclusively within combination regimens, principally BPaL and BPaLM for highly drug-resistant pulmonary tuberculosis. Also supplied for regimen-development and co-packaged blister programmes.
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