Procaine Benzylpenicillin
Also known as: Wycillin, Bicillin C-R (in combination), Depocillin (veterinary)
CAS Number: 54-35-3
Intermediate-Acting Depot Penicillin (Beta-Lactam)
Pharmacopeia Standards
Mechanism of Action
Procaine benzylpenicillin is a sparingly soluble 1:1 salt that dissolves slowly from the intramuscular depot, releasing benzylpenicillin over roughly twenty-four hours. Liberated benzylpenicillin inactivates penicillin-binding proteins and prevents peptidoglycan cross-linking. The procaine moiety also provides local anaesthesia at the injection site, improving tolerability of the large-volume suspension.
Technical Specifications
| Generic / INN Name | Procaine Benzylpenicillin |
| CAS Registry Number | 54-35-3 |
| Molecular Formula | C29H38N4O6S |
| Molecular Weight | 570.70 g/mol g/mol |
| Typical Purity | NLT 96.0% and NMT 102.0% of total penicillins; procaine content 39.0-42.0% (anhydrous basis) |
| Storage Conditions | Store below 25 C in well-closed, light-resistant containers; protect from humidity and heat. |
| Shelf Life | 24 months for sterile grade; 36 months for veterinary non-sterile grade |
| Category | Penicillins |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile suspension for intramuscular injection; fixed combinations with benzathine benzylpenicillin; large-volume veterinary injectable and intramammary products.
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