Pyrazinamide
Also known as: Pyzina, P-Zide, Rifater component, Zinamide, Tebrazid
CAS Number: 98-96-4
Antitubercular (Nicotinamide Analogue)
Pharmacopeia Standards
Mechanism of Action
Pyrazinamide is a prodrug converted by mycobacterial pyrazinamidase (PncA) into pyrazinoic acid, which accumulates in the acidic environment of the phagolysosome. The protonated acid re-enters the bacillus, acidifies the cytoplasm and disrupts membrane energetics and transport. It also interferes with trans-translation via ribosomal protein S1, giving it unique sterilising activity against semi-dormant persister organisms that other agents do not reach.
Technical Specifications
| Generic / INN Name | Pyrazinamide |
| CAS Registry Number | 98-96-4 |
| Molecular Formula | C5H5N3O |
| Molecular Weight | 123.11 g/mol g/mol |
| Typical Purity | 99.0% - 101.0% (on dried basis, USP/BP assay) |
| Storage Conditions | Store in well-closed containers below 25 degrees C in a dry place, protected from light |
| Shelf Life | 60 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 400 mg, 500 mg and 750 mg pyrazinamide tablets, dispersible paediatric tablets, and as the Z component of HRZE and RHZ fixed-dose combinations. Also used in shortened first-line regimens and in MDR-TB regimen design where drug susceptibility is confirmed.
Manufacturers (0+)
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