Pyrimethamine
Also known as: Daraprim, Fansidar (with sulfadoxine), Malocide, Pyrimon
CAS Number: 58-14-0
Antimalarial / Antiprotozoal (Dihydrofolate Reductase Inhibitor)
Pharmacopeia Standards
Mechanism of Action
Pyrimethamine selectively inhibits plasmodial and toxoplasmal dihydrofolate reductase, an enzyme for which it has orders of magnitude greater affinity than for the human isoform. Blocking the reduction of dihydrofolate to tetrahydrofolate halts thymidylate synthesis and therefore parasite DNA replication. Combined with a sulfonamide acting one step upstream, the two-point folate blockade produces strong synergy.
Technical Specifications
| Generic / INN Name | Pyrimethamine |
| CAS Registry Number | 58-14-0 |
| Molecular Formula | C12H13ClN4 |
| Molecular Weight | 248.71 g/mol g/mol |
| Typical Purity | Not less than 99.0% (assay), on the dried basis |
| Storage Conditions | Store in tight, light-resistant containers below 30°C; protect from light |
| Shelf Life | 60 months in original sealed packaging |
| Category | Antimalarials |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Fixed-dose sulfadoxine-pyrimethamine tablets for malaria chemoprevention; combination therapy with sulfadiazine for toxoplasmosis; veterinary antiprotozoal use.
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