Remdesivir
Also known as: Veklury, Cipremi, Covifor, Remdac, Redyx, Desrem
CAS Number: 1809249-37-3
Antiviral (Broad-Spectrum RNA Polymerase Inhibitor)
Pharmacopeia Standards
Mechanism of Action
Remdesivir is a phosphoramidate ProTide prodrug of an adenosine C-nucleoside analogue, converted intracellularly to the active triphosphate GS-443902. The triphosphate is incorporated by coronavirus RNA-dependent RNA polymerase in place of adenosine triphosphate and causes delayed chain termination three nucleotides downstream. The 1-cyano substituent also creates a steric clash that resists removal by the viral proofreading exonuclease.
Technical Specifications
| Generic / INN Name | Remdesivir |
| CAS Registry Number | 1809249-37-3 |
| Molecular Formula | C27H35N6O8P |
| Molecular Weight | 602.58 g/mol g/mol |
| Typical Purity | Not less than 98.0% by HPLC; diastereomeric purity not less than 98.5% |
| Storage Conditions | Store at 2 to 8 degrees C in tightly closed, light-resistant containers under nitrogen; protect from moisture. |
| Shelf Life | 24 months from date of manufacture in original sealed packing |
| Category | Antivirals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for sterile lyophilised powder for injection 100 mg vials and for cyclodextrin-solubilised concentrate for solution for infusion used in hospital antiviral formulations.
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