Rifabutin
Also known as: Mycobutin, Rifabin, R-Butin, Ricobutin
CAS Number: 72559-06-9
Antitubercular / Antimycobacterial (Rifamycin, Ansamycin)
Pharmacopeia Standards
Mechanism of Action
Rifabutin binds the beta subunit of bacterial DNA-dependent RNA polymerase and blocks the elongation of nascent messenger RNA, shutting down transcription. Its spiro-piperidyl ansamycin structure retains activity against many rifampicin-resistant strains carrying certain rpoB mutations. Rifabutin is a substantially weaker inducer of cytochrome P450 3A4 than rifampicin, which is why it is preferred where antiretroviral or immunosuppressant co-administration is a concern.
Technical Specifications
| Generic / INN Name | Rifabutin |
| CAS Registry Number | 72559-06-9 |
| Molecular Formula | C46H62N4O11 |
| Molecular Weight | 847.01 g/mol g/mol |
| Typical Purity | 96.0% - 102.0% (on anhydrous, solvent-free basis, USP assay) |
| Storage Conditions | Store at 2-8 degrees C or below 25 degrees C in tightly closed, light-resistant containers under nitrogen; protect from light and oxidation |
| Shelf Life | 36 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 150 mg rifabutin capsules and for compounded mycobacterial regimens. Used in tuberculosis regimens requiring reduced CYP3A4 induction and in Mycobacterium avium complex therapy and prophylaxis.
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