Rifapentine
Also known as: Priftin, Rifapent, P-Tin
CAS Number: 61379-65-5
Antitubercular (Long-Acting Rifamycin)
Pharmacopeia Standards
Mechanism of Action
Rifapentine inhibits DNA-dependent RNA polymerase by binding its beta subunit, arresting bacterial transcription in Mycobacterium tuberculosis. Its cyclopentyl piperazinyl substitution confers a markedly longer elimination half-life than rifampicin, sustaining suppressive concentrations between widely spaced doses. That pharmacokinetic profile is what makes once-weekly and short-course regimens feasible.
Technical Specifications
| Generic / INN Name | Rifapentine |
| CAS Registry Number | 61379-65-5 |
| Molecular Formula | C47H64N4O12 |
| Molecular Weight | 877.03 g/mol g/mol |
| Typical Purity | 96.0% - 102.0% (on anhydrous basis, USP assay) |
| Storage Conditions | Store below 25 degrees C in tightly closed, light-resistant containers under inert atmosphere; protect from light, heat and moisture |
| Shelf Life | 36 months from date of manufacture when stored as directed |
| Category | Anti-Tubercular Agents |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 150 mg and 300 mg rifapentine tablets used in short-course TB preventive therapy regimens such as 3HP and 1HP, and in four-month rifapentine-moxifloxacin treatment regimens for drug-susceptible pulmonary TB.
Manufacturers (0+)
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