Ritonavir
Also known as: Norvir, Ritomune (component of Kaletra, Aluvia, Paxlovid, boosted PI regimens)
CAS Number: 155213-67-5
HIV Protease Inhibitor / Pharmacokinetic Enhancer
Pharmacopeia Standards
Mechanism of Action
Ritonavir is a peptidomimetic inhibitor that binds the catalytic site of HIV-1 aspartyl protease, preventing cleavage of the gag and gag-pol polyproteins and yielding immature, non-infectious virions. At the low doses used clinically its dominant role is pharmacokinetic boosting through potent mechanism-based inhibition of cytochrome P450 3A4 and inhibition of P-glycoprotein. This raises plasma exposure of co-administered protease inhibitors and other CYP3A4 substrates.
Technical Specifications
| Generic / INN Name | Ritonavir |
| CAS Registry Number | 155213-67-5 |
| Molecular Formula | C37H48N6O5S2 |
| Molecular Weight | 720.94 g/mol g/mol |
| Typical Purity | Not less than 98.0% on anhydrous basis; total impurities NMT 1.5% |
| Storage Conditions | Store at 2 to 8 degrees C or below 25 degrees C per specification, in tightly closed containers with desiccant, protected from light and moisture. |
| Shelf Life | 24 to 36 months depending on solid form and packaging configuration |
| Category | Antiretrovirals (HIV) |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for lopinavir-ritonavir and atazanavir or darunavir boosting tablets, heat-stable paediatric pellets and granules, and as the pharmacokinetic enhancer component of nirmatrelvir-based antiviral packs.
Manufacturers (0+)
View all →Do you manufacture Ritonavir? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Ritonavir? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent