Sertaconazole Nitrate
Also known as: Ertaczo, Onabet, Dermofix, Sertacid, Zalain
CAS Number: 99592-39-9
Imidazole antifungal — topical, benzothiophene-substituted
Pharmacopeia Standards
Mechanism of Action
Sertaconazole inhibits fungal 14-alpha-demethylase and blocks ergosterol synthesis in the manner of other imidazoles, but its benzothiophene ring is a tryptophan bioisostere that inserts directly into the fungal membrane and creates pores independently of enzyme inhibition. This second, fungicidal mechanism operates even against non-growing cells. It also shows intrinsic anti-inflammatory and antipruritic activity, which is a formulation selling point in inflamed tinea.
Technical Specifications
| Generic / INN Name | Sertaconazole Nitrate |
| CAS Registry Number | 99592-39-9 |
| Molecular Formula | C20H15Cl3N2OS·HNO3 |
| Molecular Weight | 500.78 g/mol |
| Typical Purity | 98.5–101.0% (on dried basis) |
| Storage Conditions | Store below 25°C in tightly closed, light-resistant containers; protect from light and moisture |
| Shelf Life | 48 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Tinea pedis interdigitalis, tinea corporis and cruris, cutaneous candidiasis, pityriasis versicolor, seborrhoeic dermatitis, vulvovaginal candidiasis
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