Spectinomycin Hydrochloride
Also known as: Trobicin, Spectam, Adspec, Prospec, Stanilo
CAS Number: 21736-83-4
Aminocyclitol Antibacterial
Pharmacopeia Standards
Mechanism of Action
Spectinomycin binds helix 34 of the 16S rRNA in the 30S subunit and blocks the EF-G-catalysed translocation step of protein synthesis without causing the codon misreading typical of true aminoglycosides. Inhibition is bacteriostatic and reversible, which distinguishes it pharmacologically from gentamicin-class agents. It lacks the nephrotoxic and ototoxic profile associated with aminoglycosides proper.
Technical Specifications
| Generic / INN Name | Spectinomycin Hydrochloride |
| CAS Registry Number | 21736-83-4 |
| Molecular Formula | C14H24N2O7 . 2HCl . 5H2O |
| Molecular Weight | 495.35 g/mol g/mol |
| Typical Purity | NLT 603 micrograms of spectinomycin per mg on the anhydrous basis (USP); water content consistent with the pentahydrate |
| Storage Conditions | Store below 25 degrees C in airtight containers protected from light and moisture; sterile grade under aseptic control |
| Shelf Life | 36-48 months from date of manufacture depending on grade |
| Category | Aminoglycosides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Sterile powder for intramuscular injection in human use, and very substantial veterinary volumes as water-soluble powder, injectable solution and combination products with lincomycin for poultry and swine.
Manufacturers (0+)
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