Sulfacetamide Sodium
Also known as: Bleph-10, Klaron, Ovace, Albucid, Sulamyd
CAS Number: 127-56-0
Topical and ophthalmic sulfonamide antibacterial
Pharmacopeia Standards
Mechanism of Action
Sulfacetamide sodium competitively inhibits bacterial dihydropteroate synthase and prevents synthesis of folic acid from para-aminobenzoic acid, giving a bacteriostatic effect against common ocular and cutaneous pathogens. The sodium salt is highly water soluble and near neutral in solution, which allows the high concentrations used in eye drops without excessive irritation. In acne and seborrhoeic dermatitis it is usually paired with sulfur for a combined antibacterial and keratolytic effect.
Technical Specifications
| Generic / INN Name | Sulfacetamide Sodium |
| CAS Registry Number | 127-56-0 |
| Molecular Formula | C8H9N2NaO3S (monohydrate C8H9N2NaO3S.H2O) |
| Molecular Weight | 236.23 g/mol anhydrous; 254.24 g/mol as monohydrate g/mol |
| Typical Purity | 99.0-101.0% on anhydrous basis; water content 5.0-8.0% for monohydrate grade |
| Storage Conditions | Store in tight, light-resistant containers at 15-30 C; protect strictly from light to prevent discolouration |
| Shelf Life | 48 months from date of manufacture in original light-protected packing |
| Category | Sulfonamides |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Ophthalmic solutions and ointments at 10-30%, topical lotions, cleansers and suspensions for acne vulgaris, rosacea and seborrhoeic dermatitis, often in combination with sulfur.
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