Tedizolid Phosphate
Also known as: Sivextro, Sivextro IV
CAS Number: 856867-55-5
Second-generation oxazolidinone antibacterial (prodrug)
Mechanism of Action
Tedizolid phosphate is a water-soluble phosphate ester prodrug rapidly cleaved by plasma phosphatases to the active moiety tedizolid. Tedizolid binds the 23S rRNA of the 50S ribosomal subunit and prevents assembly of the functional 70S initiation complex, halting protein synthesis at the earliest step. Its D-ring hydroxymethyl and additional binding contacts preserve activity against many linezolid-resistant strains carrying the cfr gene.
Technical Specifications
| Generic / INN Name | Tedizolid Phosphate |
| CAS Registry Number | 856867-55-5 |
| Molecular Formula | C17H16FN6O6P |
| Molecular Weight | 450.32 g/mol g/mol |
| Typical Purity | NLT 98.5% by HPLC; single unknown impurity NMT 0.10%; chiral purity NLT 99.5% S-enantiomer |
| Storage Conditions | Store at 2-8 C in tightly sealed, light-resistant containers under inert atmosphere |
| Shelf Life | 36 months from date of manufacture under recommended cold-chain storage |
| Category | Oxazolidinones |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Once-daily 200 mg oral tablets and lyophilised powder for IV infusion for acute bacterial skin and skin structure infections caused by MRSA and other resistant Gram-positive organisms.
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