Terbinafine Hydrochloride
Also known as: Lamisil, Terbicip, Sebifin, Zimig, Terbinaforce, Tinaderm
CAS Number: 78628-80-5
Allylamine antifungal — systemic and topical
Pharmacopeia Standards
Mechanism of Action
Terbinafine inhibits squalene epoxidase, an early non-cytochrome enzyme of the fungal sterol pathway, which both starves the cell of ergosterol and causes toxic intracellular accumulation of squalene. The squalene build-up is directly fungicidal against dermatophytes, distinguishing allylamines from the fungistatic azoles. Because the target is not a cytochrome P450, terbinafine has a comparatively clean drug-interaction profile, although it does inhibit CYP2D6.
Technical Specifications
| Generic / INN Name | Terbinafine Hydrochloride |
| CAS Registry Number | 78628-80-5 |
| Molecular Formula | C21H25N·HCl |
| Molecular Weight | 327.89 g/mol |
| Typical Purity | 98.5–101.0% (on anhydrous basis) |
| Storage Conditions | Store below 25°C in tightly closed, light-resistant containers in a dry place; protect from light |
| Shelf Life | 60 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Onychomycosis of fingernail and toenail, tinea capitis, tinea pedis, cruris and corporis, cutaneous candidiasis, pityriasis versicolor as topical
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