Thiamphenicol
Also known as: Urfamycine, Thiophenicol, Glitisol, Fluimucil Antibiotic (as thiamphenicol glycinate)
CAS Number: 15318-45-3
Amphenicol antibiotic (methylsulfonyl analogue)
Pharmacopeia Standards
Mechanism of Action
Thiamphenicol is the methylsulfonyl analogue of chloramphenicol and inhibits bacterial protein synthesis by binding the 50S ribosomal subunit and blocking peptidyl transferase activity. Replacing the nitro group with a methylsulfonyl group removes the nitroreduction pathway implicated in idiosyncratic aplastic anaemia, giving a markedly cleaner haematological profile. It is excreted largely unchanged in urine, which underpins its use in urogenital and respiratory indications.
Technical Specifications
| Generic / INN Name | Thiamphenicol |
| CAS Registry Number | 15318-45-3 |
| Molecular Formula | C12H15Cl2NO5S |
| Molecular Weight | 356.22 g/mol g/mol |
| Typical Purity | 98.0-102.0% on anhydrous basis; total impurities NMT 1.0% |
| Storage Conditions | Store below 25 C in tightly closed, light-resistant containers away from moisture |
| Shelf Life | 48 months from date of manufacture in original unopened packing |
| Category | Amphenicols |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Oral capsules and granules for respiratory and urogenital infection, thiamphenicol glycinate acetylcysteinate for inhalation and injection, and veterinary preparations for swine and poultry in markets that permit amphenicol use.
Manufacturers (0+)
View all →Do you manufacture Thiamphenicol? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Thiamphenicol? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent