Valacyclovir Hydrochloride
Also known as: Valtrex, Valcivir, Valavir, Zelitrex
CAS Number: 124832-27-5
Antiviral (Nucleoside Analogue Prodrug, Anti-Herpes)
Pharmacopeia Standards
Mechanism of Action
Valacyclovir is the L-valyl ester prodrug of acyclovir, absorbed via the intestinal peptide transporter PEPT1 and then rapidly hydrolysed by hepatic valacyclovir hydrolase to release acyclovir. This route raises oral bioavailability of acyclovir roughly three to five fold. The liberated acyclovir is activated by viral thymidine kinase and cellular kinases to the triphosphate, which inhibits viral DNA polymerase and terminates chain elongation.
Technical Specifications
| Generic / INN Name | Valacyclovir Hydrochloride |
| CAS Registry Number | 124832-27-5 |
| Molecular Formula | C13H21ClN6O4 |
| Molecular Weight | 360.80 g/mol g/mol |
| Typical Purity | Not less than 98.0% calculated on anhydrous basis as valacyclovir |
| Storage Conditions | Store below 25 degrees C in tightly closed containers with desiccant, protected from light and moisture. |
| Shelf Life | 36 months from date of manufacture in original sealed packing |
| Category | Antivirals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for 500 mg and 1000 mg film-coated tablets, dispersible tablets and oral suspension formulations used across herpes simplex, herpes zoster and cytomegalovirus prophylaxis product lines.
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