Voriconazole
Also known as: Vfend, Voritek, Vorizol, Vozole, Voriz
CAS Number: 137234-62-9
Second-generation triazole antifungal — systemic
Pharmacopeia Standards
Mechanism of Action
Voriconazole is a fluoropyrimidine-substituted derivative of fluconazole that binds fungal CYP51 with substantially higher affinity, blocking 14-alpha-demethylation of lanosterol. The structural modification extends the spectrum to moulds, giving fungicidal activity against Aspergillus species and useful coverage of Scedosporium and Fusarium. It is metabolised chiefly by CYP2C19, whose polymorphism produces wide interindividual exposure differences.
Technical Specifications
| Generic / INN Name | Voriconazole |
| CAS Registry Number | 137234-62-9 |
| Molecular Formula | C16H14F3N5O |
| Molecular Weight | 349.31 g/mol |
| Typical Purity | 98.0–102.0% (on anhydrous basis) |
| Storage Conditions | Store at 2–25°C in tightly closed, light-resistant containers under nitrogen blanket; protect from moisture |
| Shelf Life | 36 months from date of manufacture |
| Category | Antifungals |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Invasive aspergillosis, candidaemia in non-neutropenic patients, oesophageal candidiasis, serious Scedosporium and Fusarium infections, fungal keratitis, empirical therapy in persistently febrile neutropenia
Manufacturers (0+)
View all →Do you manufacture Voriconazole? Add your free listing and reach global buyers.
Add listing — FreeCan you supply Voriconazole? List as an authorised distributor or export house.
Register as traderEarn commission by connecting buyers with verified API suppliers. Free to join.
Become an agent