Zidovudine
Also known as: Retrovir, Zidovir, Zidovex (component of Combivir, Duovir, Trioday)
CAS Number: 30516-87-1
Nucleoside Reverse Transcriptase Inhibitor (NRTI)
Pharmacopeia Standards
Mechanism of Action
Zidovudine is a thymidine analogue in which the 3-hydroxyl group is replaced by an azido group. Cellular thymidine kinase and downstream kinases convert it to zidovudine triphosphate, which competitively inhibits HIV-1 reverse transcriptase relative to thymidine triphosphate. Once incorporated, the azido group prevents formation of the next phosphodiester bond and terminates proviral DNA elongation.
Technical Specifications
| Generic / INN Name | Zidovudine |
| CAS Registry Number | 30516-87-1 |
| Molecular Formula | C10H13N5O4 |
| Molecular Weight | 267.24 g/mol g/mol |
| Typical Purity | Not less than 97.0% and not more than 102.0% on dried basis (USP) |
| Storage Conditions | Store below 25 degrees C in tightly closed containers protected from light and moisture. |
| Shelf Life | 60 months from date of manufacture in original sealed packing |
| Category | Antiretrovirals (HIV) |
Specifications are indicative and intended for sourcing reference only. Always confirm against the supplier's Certificate of Analysis and the applicable pharmacopeial monograph before issuing a purchase specification.
Typical Applications
Bulk API for zidovudine and lamivudine fixed-dose tablets, triple combinations with nevirapine, paediatric syrups and dispersible tablets, and intravenous infusion concentrates used in prevention of mother-to-child transmission protocols.
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